G protein-coupled receptors (GPCRs) are druggable proteins expressed at the cell surface, and are extensively used as therapeutic
targets (Hauser et al., 2017 PMID 29075003). About a hundred GPCRs are orphans (oGPCRs), as their natural ligand and function is
unknown, and more than half are expressed in the brain. Brain oGPCRs represent a huge potential to be novel therapeutic targets in
neurological and psychiatric diseases (Davenport et al., 2013 PMID 23686350). Characterizing their expression pattern is an essential first
step to investigate the role of these receptors in brain function, and position them in potential disease areas. Here, you will find brain mapping
for 78 brain oGPCRs (Regard et al., 2008 PMID 18984166) across the whole mouse brain using two distinct methods of in situ hybridization (ISH).
Use oGPCR search to find ISH for a specific brain oGPCR of interest.